Structure of PDB 5ivf Chain A

Receptor sequence
>5ivfA (length=308) Species: 9606 (Homo sapiens) [Search protein sequence]
EFVPPPECPVFEPSWEEFTDPLSFIGRIRPLAEKTGICKIRPPKDWQPPF
ACEVKSFRFTPRVQRLNELEAMRPREAFGFEQAVREYTLQSFGEMADNFK
SDYFNMPVHMVPTELVEKEFWRLVSSIEEDVIVEYGADISSKDFGSGFPV
KDGRRKILPEEEEYALSGWNLNNMPVLEQSVLAHINKVPWLYVGMCFSSF
CWHIEDHWSYSINYLHWGEPKTWYGVPSHAAEQLEEVMRELAPELFESQP
DLLHQLVTIMNPNVLMEHGVPVYRTNQCAGEFVVTFPRAYHSGFNQGYNF
AEAVNFCT
3D structure
PDB5ivf Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds.
ChainA
Resolution1.683 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y472 H483 E485 H571 A583
Catalytic site (residue number reindexed from 1) Y192 H203 E205 H291 A303
Enzyme Commision number 1.14.11.67: [histone H3]-trimethyl-L-lysine(4) demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6EB A R73 Q75 Y409 A411 Y472 F480 H483 E485 K501 W503 H571 R62 Q64 Y135 A137 Y192 F200 H203 E205 K221 W223 H291 PDBbind-CN: -logKd/Ki=4.40,Kd>40uM
BindingDB: IC50=<100nM
BS02 MN A H483 E485 H571 H203 E205 H291
External links
PDB RCSB:5ivf, PDBe:5ivf, PDBj:5ivf
PDBsum5ivf
PubMed27427228
UniProtP29375|KDM5A_HUMAN Lysine-specific demethylase 5A (Gene Name=KDM5A)

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