Structure of PDB 5iut Chain A

Receptor sequence
>5iutA (length=460) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence]
KLPPGPSPLPVLGNLLQMDRKGLLRSFLRLREKYGDVFTVYLGSRPVVVL
CGTDAIREALVDQAEAFSGRGKIAVVDPIFQGYGVIFANGERWRALRRFS
LATMRDFGKRSVEERIQEEARCLVEELRKSKGALLDNTLLFHSITSNIIC
SIVFGKRFDYKDPVFLRLLDLWFQSFSLISSFSSQVFELFSGFLKYFPGT
HRQIYRNLQEINTFIGQSVEKHRATLDPSNPRDFIDVYLLRMEKDKSDPS
SEFHHQNLILTVLSLFFAGTETTSTTLRYGFLLMLKYPHVTERVQKEIEQ
VIGSHRPPALDDRAKMPYTDAVIHEIQRLGDLIPFGVPHTVTKDTQFRGY
VIPKNTEVFPVLSSALHDPRYFETPNTFNPGHFLDANGALKRNEGFMPFS
LGKRICLGEGIARTELFLFFTTILQNFSIASPVPPEDIDLTPRGVGNVPP
SYQIRFLARH
3D structure
PDB5iut Effect of detergent binding on cytochrome P450 2B4 structure as analyzed by X-ray crystallography and deuterium-exchange mass spectrometry.
ChainA
Resolution2.34 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) T302 F429 C436
Catalytic site (residue number reindexed from 1) T272 F399 C406
Enzyme Commision number 1.14.14.1: unspecific monooxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM A R98 I114 W121 R125 A298 G299 T302 T303 I363 V367 H369 F429 S430 R434 C436 L437 G438 A442 R70 I86 W93 R97 A268 G269 T272 T273 I333 V337 H339 F399 S400 R404 C406 L407 G408 A412
BS02 32M A L43 M46 L51 I101 L219 F297 A298 I363 L15 M18 L23 I73 L189 F267 A268 I333
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0008392 arachidonate epoxygenase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0020037 heme binding
GO:0046872 metal ion binding
GO:0070330 aromatase activity
Biological Process
GO:0006805 xenobiotic metabolic process
GO:0019373 epoxygenase P450 pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5iut, PDBe:5iut, PDBj:5iut
PDBsum5iut
PubMed27280734
UniProtP00178|CP2B4_RABIT Cytochrome P450 2B4 (Gene Name=CYP2B4)

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