Structure of PDB 5iui Chain A

Receptor sequence
>5iuiA (length=303) Species: 9606 (Homo sapiens) [Search protein sequence]
MTDYNPNYSFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGP
SPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPR
FILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEE
NHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRAGGCAMLPVKWMP
PEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGR
MDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTAL
PIE
3D structure
PDB5iui Pyrazolylamine Derivatives Reveal the Conformational Switching between Type I and Type II Binding Modes of Anaplastic Lymphoma Kinase (ALK).
ChainA
Resolution1.88 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D1249 A1251 R1253 N1254 D1270 R1279
Catalytic site (residue number reindexed from 1) D157 A159 R161 N162 D178 R187
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 45Q A L1122 F1127 A1148 V1180 L1196 E1197 M1199 A1200 G1201 G1202 L1256 G1269 L34 F39 A56 V88 L104 E105 M107 A108 G109 G110 L164 G177 PDBbind-CN: -logKd/Ki=5.00,IC50>10000nM
BindingDB: IC50=>10000nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5iui, PDBe:5iui, PDBj:5iui
PDBsum5iui
PubMed27031565
UniProtQ9UM73|ALK_HUMAN ALK tyrosine kinase receptor (Gene Name=ALK)

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