Structure of PDB 5iub Chain A

Receptor sequence
>5iubA (length=388) Species: 562,9606 [Search protein sequence]
GAPPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSL
AAADILVGVLAIPFAITISTGFCAACHGCLFIACFVLVLAQSSIFSLLAI
AIDRYIAIAIPLRYNGLVTGTRAAGIIAICWVLSFAIGLTPMLGWNNCGQ
PKEGKAHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYL
RIFAAARRQLADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDA
QKMKDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRNAYIQKY
LERARSTLQKEVHAAKSAAIIAGLFALCWLPLHIINCFTFFCPDCSHAPL
WLMYLAIVLAHTNSVVNPFIYAYRIREFRQTFRKIIRS
3D structure
PDB5iub Controlling the Dissociation of Ligands from the Adenosine A2A Receptor through Modulation of Salt Bridge Strength.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6DV A L85 F168 E169 M177 W246 L249 H250 N253 H264 A265 L267 I274 L87 F170 E171 M179 W329 L332 H333 N336 H347 A348 L350 I357 MOAD: Ki=0.35nM
PDBbind-CN: -logKd/Ki=9.46,Ki=0.35nM
BS02 CLR A A72 G76 I80 A74 G78 I82
BS03 CLR A P248 S263 P331 S346
BS04 CLR A L247 C254 F255 F258 C259 L330 C337 F338 F341 C342
Gene Ontology
Molecular Function
GO:0001609 G protein-coupled adenosine receptor activity
GO:0004930 G protein-coupled receptor activity
GO:0005506 iron ion binding
GO:0009055 electron transfer activity
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:0001973 G protein-coupled adenosine receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0022900 electron transport chain
Cellular Component
GO:0016020 membrane
GO:0042597 periplasmic space

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Cellular Component
External links
PDB RCSB:5iub, PDBe:5iub, PDBj:5iub
PDBsum5iub
PubMed27312113
UniProtP0ABE7|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC);
P29274|AA2AR_HUMAN Adenosine receptor A2a (Gene Name=ADORA2A)

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