Structure of PDB 5isl Chain A

Receptor sequence
>5islA (length=306) Species: 9606 (Homo sapiens) [Search protein sequence]
EFVPPPECPVFEPSWEEFTDPLSFIGRIRPLAEKTGICKIRPPKDWQPPF
ACEVKSFRFTPRVQRLNELEAMTRPREAFGFEQAVREYTLQSFGEMADNF
KSDYFNMPVHMVPTELVEKEFWRLVSSIEEDVIVEYGADISSKDFGSGFP
VKDGRRKILPEEEEYALSGWNLNNMPVLEQSVLMKVPWLYVGMCFSSFCW
HIEDHWSYSINYLHWGEPKTWYGVPSHAAEQLEEVMRELAPELFESQPDL
LHQLVTIMNPNVLMEHGVPVYRTNQCAGEFVVTFPRAYHSGFNQGYNFAE
AVNFCT
3D structure
PDB5isl Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds.
ChainA
Resolution1.694 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y472 H483 E485 H571 A583
Catalytic site (residue number reindexed from 1) Y190 H201 E203 H289 A301
Enzyme Commision number 1.14.11.67: [histone H3]-trimethyl-L-lysine(4) demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MMK A Y409 W470 Y472 F480 H483 E485 K501 W503 H571 V584 N585 Y136 W188 Y190 F198 H201 E203 K219 W221 H289 V302 N303 MOAD: Kd=0.052uM
PDBbind-CN: -logKd/Ki=7.28,Kd=0.052uM
BS02 MN A H483 E485 H571 H201 E203 H289
External links
PDB RCSB:5isl, PDBe:5isl, PDBj:5isl
PDBsum5isl
PubMed27427228
UniProtP29375|KDM5A_HUMAN Lysine-specific demethylase 5A (Gene Name=KDM5A)

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