Structure of PDB 5iry Chain A

Receptor sequence

>5iryA (length=539) Species: 9606 (Homo sapiens) [Search protein sequence]

RWAPIPASLMENSLGPFPQHVQQIQSDAAQNYTIFYSISGPGVDKEPFNL
FYIEKDTGDIFCTRSIDREKYEQFALYGYATTADGYAPEYPLPLIIKIED
DNDNAPYFEHRVTIFTVPENCRSGTSVGKVTATDLDEPDTLHTRLKYKIL
QQIPDHPKHFSIHPDTGVITTTTPFLDREKCDTYQLIMEVRDMGGQPFGL
FNTGTITISLEDENDNPPSFTETSYVTEVEENRIDVEILRMKVQDQDLPN
TPHSKAVYKILQGNENGNFIISTDPNTNEGVLCVVKPLNYEVNRQVILQV
GVINEAQFSKAASSQTPTMCTTTVTVKIIDSDEGPECHPPVKVIQSQDGF
PAGQELLGYKALDPEISSGEGLRYQKLGDEDNWFEINQHTGDLRTLKVLD
RESKFVKNNQYNISVVAVDAVGRSCTGTLVVHLDDYNDHAPQIDKEVTIC
QNNEDFAVLKPVDPDGPENGPPFQFFLDNSASKNWNIEEKDGKTAILRQR
QNLDYNYYSVPIQIKDRHGLVATHMLTVRVCDCSTPSEC

3D structure

PDB

5iry Structural basis of adhesive binding by desmocollins and desmogleins.

Chain

Resolution

3.095 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	CA	A	E11 D67 E69 D103	E11 D67 E69 D103
BS02	CA	A	N102 N104 D134 D136 H142 D192	N102 N104 D134 D136 H142 D192
BS03	CA	A	N214 N216 D245 D247 H253 N304	N214 N216 D245 D247 H253 N304
BS04	CA	A	E231 E291 D330 S331 D332	E231 E291 D330 S331 D332
BS05	CA	A	D348 D400 E402 D438	D348 D400 E402 D438
BS06	CA	A	R401 E402 D435 Y436 D438 D465	R401 E402 D435 Y436 D438 D465
BS07	CA	A	N437 H439 D463 D465 N469 D516	N437 H439 D463 D465 N469 D516
BS08	CA	A	E231 N289 E291 E333	E231 N289 E291 E333
BS09	CA	A	D332 E333 E365	D332 E333 E365
BS10	CA	A	E11 E69 D100 D101 D103 D136	E11 E69 D100 D101 D103 D136
BS11	CA	A	E119 N120 D177 D215	E119 N120 D177 D215
BS12	CA	A	E119 E179 D212 E213 D215 D247	E119 E179 D212 E213 D215 D247

Gene Ontology

	Molecular Function
GO:0005509	calcium ion binding

	Biological Process
GO:0007155	cell adhesion
GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
GO:0098609	cell-cell adhesion

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:5iry, PDBe:5iry, PDBj:5iry
PDBsum	5iry
PubMed	27298358
UniProt	Q08554\|DSC1_HUMAN Desmocollin-1 (Gene Name=DSC1)

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