Structure of PDB 5irm Chain A

Receptor sequence
>5irmA (length=767) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence]
EFEAAACKKYMSKLRTIVAAQSRFLSTLCLEDIYTENTLEVRTPAALGLE
ELFSPNGHLNEDADTVLVVGEAGSGKSTLLQQVHLLWATGQDFQEFLFVF
PFSCRQLQCVARPLSVMTLLFEHCCWPDVGQQDVFQFLLDHPDRILLTFD
GFDEFKFKFTDHERHCSPTDPTSVQTLLFNLLQGNLLKNARKVLTSRPDA
VSAFLRKYVRTEFNLKGFSEEGIELYLRKCHREPGVADRLIHLLQTTSAL
HGLCHLPVFSWMVSKCHQELLLQDGGSPKTTTDMYLLILQHFLRHALGPS
LLQGRLPTLLRLGQLALWGLGMCCYVFSAQQLQAAQVDPDDISLGFLVQA
QGVVPGSTAPLEFLHITFQCFLAAFYLVLSTDVPTASLRYLFNCESTVAA
LLQKTEPHNLQITAAFLAGLLSREHRDLLAACQASERSLLRRRACARWCL
ARSLHKHFRSIAMPGFLWLIRSLYEMQEERLAQEAVRGLNVEHLKLTFCG
VGPAECAALAFVLRHLRRPVALQLDHNSVGDIGVEQLLPCLGACKALYLR
DNNISDRGICKLIEHALHCEQLQKLALFNNKLTDGCAHSVAQLLACKQNF
LALRLGNNHITAEGAQVLAEGLRDNSSLQFLGFWGNKVGDKGAQALAEAL
SDHQSLKWLSLVGNNIGSVGAQALASMLEKNVALEELCLEENHLQDAGVC
SLAEGLKRNSSLKVLKLSNNCITFVGAEALLQALASNDTILEVWLRGNPF
SPEEMEALSHRDSRLLL
3D structure
PDB5irm Crystal structure of NOD2 and its implications in human disease.
ChainA
Resolution3.31 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A T219 Y232 T233 G282 G284 K285 S286 T287 F427 Y435 P466 V467 H583 T27 Y34 T35 G73 G75 K76 S77 T78 F218 Y226 P257 V258 H365
External links
PDB RCSB:5irm, PDBe:5irm, PDBj:5irm
PDBsum5irm
PubMed27283905
UniProtG1T469|NOD2_RABIT Nucleotide-binding oligomerization domain-containing protein 2 (Gene Name=NOD2)

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