Structure of PDB 5ir5 Chain A

Receptor sequence
>5ir5A (length=626) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence]
IPPSLPQYDNLAGKLARRAVLTSKKLVYVWTENFANVKGVPMARSVPLGE
LPNVDWLLKTAGVIVELIVNFVASLPASAAAQFERIAAGLSGDLEAARQV
HEALLEEAKNDPAAAGSLLLRFTELQTRVIALLTRVGLLVDDILKSADGL
NRFRAVFGTLRLPEVADSFRDDEAFAYWRVAGPNPLLIRRVDALPANFPL
GEEQFRRVMGADDSLLEAAASRRLYLLDYAELGKLAPSGAVDKLLTGTGF
AYAPIALFALGKDRAGLLPVAIQCGQDPATHPMFVRPAESESDLYWGWQM
AKTVVQVAEENYHEMFVHLAQTHLVSEAFCLATQRTLAPSHPLHVLLAPH
FEGTLFINEGAARILLPSAGFIDVMFAAPIQDTQATAGGNRLGFDFYRGM
LPESLKARNVDDPAALPDYPYRDDGLLVWNAIRQWAADYVAVYYASDGDV
TADVELAAWVGEVIGSGKVAGFRPITGRSQLVEVLTMVIFTASAQHAAVN
FPQPSMMTYAPAICAMSAAPAPDSPSGKSEADWLKMMPPTLVALEKVNIY
HLLGSVYHGRLGDYRQTGFPYAPVFSDRRVTASGGPLERFQARLKEVEAT
IRTRNQARRKPYEYLLPSRIPASTNI
3D structure
PDB5ir5 Structural and functional basis of phospholipid oxygenase activity of bacterial lipoxygenase from Pseudomonas aeruginosa.
ChainA
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H377 H382 H555 N559 I685
Catalytic site (residue number reindexed from 1) H318 H323 H496 N500 I626
Enzyme Commision number 1.13.11.-
1.13.11.33: arachidonate 15-lipoxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FE2 A H377 H382 H555 N559 I685 H318 H323 H496 N500 I626
BS02 ZPE A L182 G186 D190 E373 H382 F415 I416 A420 L424 N607 L133 G137 D141 E314 H323 F356 I357 A361 L365 N548
Gene Ontology
Molecular Function
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0046872 metal ion binding
Biological Process
GO:0034440 lipid oxidation

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Molecular Function
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Biological Process
External links
PDB RCSB:5ir5, PDBe:5ir5, PDBj:5ir5
PDBsum5ir5
PubMed27500637
UniProtQ9I4G8|LOXA_PSEAE Lipoxygenase LoxA (Gene Name=loxA)

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