Structure of PDB 5iqe Chain A

Receptor sequence
>5iqeA (length=295) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
NATNVKAMKYLIEHYFDNFKVDSIEIIGSGYDSVAYLVNNEYIFKTKFST
NKGYAKEKAIYNFLNTNLETNVKIPNIEYSYISDELSILGYKEIKGTFLT
PEIYSTMSEEEQNLLKRDIASFLRQMHGLDYTDISECTIDNKQNVLEEYI
LLRETIYNDLTDIEKDYIESFMERLNATTVFEGKKCLCHNDFSCNHLLLD
GNNRLTGIIDFGDSGIIDEYCDFIYLLEDSEEEIGTNFGEDILRMYGNID
IEKAKEYQDIVEEYYPIETIVYGIKNIKQEFIENGRKEIYKRTYK
3D structure
PDB5iqe Antibiotic Binding Drives Catalytic Activation of Aminoglycoside Kinase APH(2)-Ia.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.7.1.190: aminoglycoside 2''-phosphotransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GNP A I224 K226 Y237 Y274 E276 I277 F281 H379 I392 D393 I43 K45 Y54 Y91 E93 I94 F98 H196 I209 D210
BS02 NMY A D374 S376 D396 Y408 E415 E445 Y448 E451 D191 S193 D213 Y225 E232 E262 Y265 E268
BS03 MG A H379 D393 H196 D210
External links
PDB RCSB:5iqe, PDBe:5iqe, PDBj:5iqe
PDBsum5iqe
PubMed27161980
UniProtP0A0C1|AACA_STAAU Bifunctional AAC/APH (Gene Name=aacA-aphD)

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