Structure of PDB 5iqd Chain A

Receptor sequence
>5iqdA (length=296) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
DDNATNVKAMKYLIEHYFDNFKVDSIEIIGSGYDSVAYLVNNEYIFKTKF
SKGYAKEKAIYNFLNTNLETNVKIPNIEYSYISDELSILGYKEIKGTFLT
PEIYSTMSEEEQNLLKRDIASFLRQMHGLDYTDISECTIDNKQNVLEEYI
LLRETIYNDLTDIEKDYIESFMERLNATTVFEGKKCLCHNDFSCNHLLLD
GNNRLTGIIDFGDSGIIDEYCDFIYLLEDSEEEIGTNFGEDILRMYGNID
IEKAKEYQDIVEEYYPIETIVYGIKNIKQEFIENGRKEIYKRTYKD
3D structure
PDB5iqd Antibiotic Binding Drives Catalytic Activation of Aminoglycoside Kinase APH(2)-Ia.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.7.1.190: aminoglycoside 2''-phosphotransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GNP A I224 K226 Y237 Y274 I277 F281 H379 I392 D393 I45 K47 Y54 Y91 I94 F98 H196 I209 D210
BS02 RIO A D374 S376 Y408 E411 E415 E416 V444 E445 Y448 E451 D191 S193 Y225 E228 E232 E233 V261 E262 Y265 E268
BS03 MG A H379 D393 H196 D210
External links
PDB RCSB:5iqd, PDBe:5iqd, PDBj:5iqd
PDBsum5iqd
PubMed27161980
UniProtP0A0C1|AACA_STAAU Bifunctional AAC/APH (Gene Name=aacA-aphD)

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