Structure of PDB 5iqc Chain A

Receptor sequence
>5iqcA (length=301) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
YDDNATNVKAMKYLIEHYFDNFKVDSIEIIGSGYDSVAYLVNNEYIFKTK
FSTNKKKGYAKEKAIYNFLNTNLETNVKIPNIEYSYISDELSILGYKEIK
GTFLTPEIYSTMSEEEQNLLKRDIASFLRQMHGLDYTDISECTIDNKQNV
LEEYILLRETIYNDLTDIEKDYIESFMERLNATTVFEGKKCLCHNDFSCN
HLLLDGNNRLTGIIDFGDSGIIDEYCDFIYLLEDSEEEIGTNFGEDILRM
YGNIDIEKAKEYQDIVEEYYPIETIVYGIKNIKQEFIENGRKEIYKRTYK
D
3D structure
PDB5iqc Antibiotic Binding Drives Catalytic Activation of Aminoglycoside Kinase APH(2)-Ia.
ChainA
Resolution2.3 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.3.1.-
2.7.1.190: aminoglycoside 2''-phosphotransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GNP A S214 I224 K226 Y274 I277 F281 H379 I392 D393 S36 I46 K48 Y96 I99 F103 H201 I214 D215
BS02 51G A D374 S376 D396 Y408 E411 E415 E416 E445 Y448 D196 S198 D218 Y230 E233 E237 E238 E267 Y270
BS03 MG A H379 D393 H201 D215
External links
PDB RCSB:5iqc, PDBe:5iqc, PDBj:5iqc
PDBsum5iqc
PubMed27161980
UniProtP0A0C1|AACA_STAAU Bifunctional AAC/APH (Gene Name=aacA-aphD)

[Back to BioLiP]