Structure of PDB 5iq6 Chain A

Receptor sequence
>5iq6A (length=576) Species: 11069 (dengue virus type 3) [Search protein sequence]
MDVIGERIKRIKEEHNSTWHYDDENPYKTWAYHGSYEVKSSMINGVVKLL
TKPWDVVPMVTQMAMTDTTPFGQQRVFKEKVDTRTPRPLPGTRKVMEITA
EWLWRTLGRNKRPRLCTREEFTKKVRTNAASAKAAVEDEEFWKLVDRERE
LHKLGKCGSCVYNMGSRAIWYMWLGVRYLEFEALGFLNEDHWFSRENSYS
GVEGEGLHKLGYILRDISKIPGGAMYADDTAGWDTRITEDDLHNEEKIIQ
QMDPEHRQLANAIFKLTYQNKVVKVQRPTTVMDIISRKDQRGSGQVGTYG
LNTFTNMEAQLVRQMEGEGVLTKADLENPHLLEKKITQWLETKGVERLKR
MAISGDDCVVKPIDDRFANALLALNDMGKVRKDIPQWQPSKGWHDWQQVP
FCSHHFHELIMKDGRKLVVPCRPQDELIGRARISQGAGWSLRETACLGKA
YAQMWSLMYFHRRDLRLASNAICSAVPVHWVPTSRTTWSIHAHHQWMTTE
DMLTVWNRVWIEENPWMEDKTPVTTWENVPYLGKREDQWCGSLIGLTSRA
TWAQNIPTAIQQVRSLIGNEEFLDYM
3D structure
PDB5iq6 Targeting flavivirus RNA dependent RNA polymerase through a pyridobenzothiazole inhibitor.
ChainA
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H712 H714 C728 C847 H405 H407 C421 C540
BS02 ZN A E437 H441 C449 E148 H152 C160
Gene Ontology
Molecular Function
GO:0003968 RNA-dependent RNA polymerase activity
GO:0005524 ATP binding
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:5iq6, PDBe:5iq6, PDBj:5iq6
PDBsum5iq6
PubMed27649989
UniProtQ6YMS4|POLG_DEN3S Genome polyprotein (Gene Name=pol)

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