Structure of PDB 5ipc Chain A

Receptor sequence

>5ipcA (length=115) Species: 9606 (Homo sapiens)

RPGGDTIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAPTHFLVIPKKHIS
QISVAEDDDESLLGHLMIVGKKCAADLGLNKGYRMVVNEGSDGGQSVYHV
NLHVLGGRQMHWPPG

3D structure

• PDB: 5ipc Caught before Released: Structural Mapping of the Reaction Trajectory for the Sofosbuvir Activating Enzyme, Human Histidine Triad Nucleotide Binding Protein 1 (hHint1).
• Chain: A
• Resolution: 1.3 Å

Enzymatic activity

• Enzyme Commision number: 3.4.22.-
  3.9.1.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	6CE	A	I18 F41 D43 I44 L53 N99 G105 Q106 S107 V108 N112 H114	I7 F30 D32 I33 L42 N88 G94 Q95 S96 V97 N101 H103	MOAD: Kd=13uM PDBbind-CN: -logKd/Ki=4.89,Kd=13uM

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0003824 catalytic activity
• GO:0005080 protein kinase C binding
• GO:0005515 protein binding
• GO:0008234 cysteine-type peptidase activity
• GO:0016787 hydrolase activity
• GO:0016929 deSUMOylase activity
• GO:0043530 adenosine 5'-monophosphoramidase activity

Biological Process

• GO:0006355 regulation of DNA-templated transcription
• GO:0006508 proteolysis
• GO:0006915 apoptotic process
• GO:0007165 signal transduction
• GO:0009154 purine ribonucleotide catabolic process
• GO:0016926 protein desumoylation
• GO:0050850 positive regulation of calcium-mediated signaling
• GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator

Cellular Component

• GO:0000118 histone deacetylase complex
• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005856 cytoskeleton
• GO:0005886 plasma membrane
• GO:0070062 extracellular exosome

External links

• PDB: RCSB:5ipc, PDBe:5ipc, PDBj:5ipc
• PDBsum: 5ipc
• PubMed: 28691797
• UniProt: P49773|HINT1_HUMAN Adenosine 5'-monophosphoramidase HINT1 (Gene Name=HINT1)