Structure of PDB 5ipa Chain A

Receptor sequence
>5ipaA (length=193) Species: 419947 (Mycobacterium tuberculosis H37Ra) [Search protein sequence]
GDDRELAILATAENLLEDRPLADISVDDLAKGAGISRPTFYFYFPSKEAV
LLTLLDRVVNQADMALQTLAENPADTDRENMWRTGINVFFETFGSHKAVT
RAGQAARATSVEVAELWSTFMQKWIAYTAAVIDAERDRGAAPRTLPAHEL
ATALNLMNERTLFASFAGEQPSVPEARVLDTLVHIWVTSIYGE
3D structure
PDB5ipa Fragment-Sized EthR Inhibitors Exhibit Exceptionally Strong Ethionamide Boosting Effect in Whole-Cell Mycobacterium tuberculosis Assays.
ChainA
Resolution1.78 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6C8 A F114 R128 W138 E180 L183 F93 R107 W117 E159 L162 MOAD: Kd=20uM
PDBbind-CN: -logKd/Ki=4.70,Kd=20uM
BS02 6C8 A I107 F110 T149 N176 N179 E180 W207 I86 F89 T128 N155 N158 E159 W186 MOAD: Kd=20uM
PDBbind-CN: -logKd/Ki=4.70,Kd=20uM
BS03 6C8 A I107 F110 W138 M142 W145 T149 N176 N179 E180 W207 I86 F89 W117 M121 W124 T128 N155 N158 E159 W186 MOAD: Kd=20uM
PDBbind-CN: -logKd/Ki=4.70,Kd=20uM
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:5ipa, PDBe:5ipa, PDBj:5ipa
PDBsum5ipa
PubMed28314097
UniProtA5U9I4

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