Structure of PDB 5ioy Chain A

Receptor sequence
>5ioyA (length=193) Species: 419947 (Mycobacterium tuberculosis H37Ra) [Search protein sequence]
GDDRELAILATAENLLEDRPLADISVDDLAKGAGISRPTFYFYFPSKEAV
LLTLLDRVVNQADMALQTLAENPADTDRENMWRTGINVFFETFGSHKAVT
RAGQAARATSVEVAELWSTFMQKWIAYTAAVIDAERDRGAAPRTLPAHEL
ATALNLMNERTLFASFAGEQPSVPEARVLDTLVHIWVTSIYGE
3D structure
PDB5ioy Fragment-Sized EthR Inhibitors Exhibit Exceptionally Strong Ethionamide Boosting Effect in Whole-Cell Mycobacterium tuberculosis Assays.
ChainA
Resolution1.77 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6C5 A F110 W145 N176 N179 W207 F89 W124 N155 N158 W186 MOAD: Kd=6uM
PDBbind-CN: -logKd/Ki=5.22,Kd=6uM
BS02 6C5 A F114 R128 W138 E180 F184 F93 R107 W117 E159 F163 MOAD: Kd=6uM
PDBbind-CN: -logKd/Ki=5.22,Kd=6uM
BS03 6C5 A L87 M102 W103 Y148 V152 E156 L66 M81 W82 Y127 V131 E135 MOAD: Kd=6uM
PDBbind-CN: -logKd/Ki=5.22,Kd=6uM
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:5ioy, PDBe:5ioy, PDBj:5ioy
PDBsum5ioy
PubMed28314097
UniProtA5U9I4

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