Structure of PDB 5ior Chain A

Receptor sequence
>5iorA (length=216) Species: 243274 (Thermotoga maritima MSB8) [Search protein sequence]
KIDILDKGFVELVDVMGNDLSAVRAARVSFDMGKDEERDRHLIEYLMKHG
HETPFEHIVFTFHVKAPIFVARQWFRHRIASYNELSGRYSKLSYEFYIPS
PERLEGYKTTIPPERVTEKISEIVDKAYRTYLELIESGVPREVARIVLPL
NLYTRFFWTVNARSLMNFLNLRADSHAQWEIQQYALAIARIFKEKCPWTF
EAFLKYAYKGDILKEV
3D structure
PDB5ior Deprotonations in the Reaction of Flavin-Dependent Thymidylate Synthase.
ChainA
Resolution1.95 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.1.1.148: thymidylate synthase (FAD).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A R78 H79 R80 I81 N169 L173 H178 R76 H77 R78 I79 N167 L171 H176
BS02 DUS A Q75 R78 R174 Q73 R76 R172 MOAD: Kd=0.17uM
Gene Ontology
Molecular Function
GO:0004799 thymidylate synthase activity
GO:0008168 methyltransferase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0050797 thymidylate synthase (FAD) activity
GO:0070402 NADPH binding
Biological Process
GO:0006231 dTMP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0032259 methylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5ior, PDBe:5ior, PDBj:5ior
PDBsum5ior
PubMed27214228
UniProtQ9WYT0|THYX_THEMA Flavin-dependent thymidylate synthase (Gene Name=thyX)

[Back to BioLiP]