Structure of PDB 5inq Chain A

Receptor sequence
>5inqA (length=255) Species: 10090 (Mus musculus) [Search protein sequence]
KGLEDSSTISFITWNIDGLDGCNLPERARGVCSCLALYSPDVVFLQEVIP
PYCAYLKKRAASYTIITGNEEGYFTAILLKKGRVKFKSQEIIPFPNTKMM
RNLLCVNVSLGGNEFCLMTSHLESTREHSAERIRQLKTVLGKMQEAPDST
TVIFAGDTNLRDQEVIKCGGLPDNVFDAWEFLGKPKHCQYTWDTKANNNL
RIPAAYKHRFDRIFFRAEEGHLIPQSLDLVGLEKLDCGRFPSDHWGLLCT
LNVVL
3D structure
PDB5inq Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2.
ChainA
Resolution1.848 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A E162 H236 S239 T240 R241 R276 W307 L315 I317 Y321 E47 H121 S124 T125 R126 R161 W192 L200 I202 Y206
BS02 CA A D132 E162 D17 E47
Gene Ontology
Molecular Function
GO:0003824 catalytic activity

View graph for
Molecular Function
External links
PDB RCSB:5inq, PDBe:5inq, PDBj:5inq
PDBsum5inq
PubMed27060144
UniProtQ9JJX7|TYDP2_MOUSE Tyrosyl-DNA phosphodiesterase 2 (Gene Name=Tdp2)

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