Structure of PDB 5in3 Chain A

Receptor sequence
>5in3A (length=324) Species: 9606 (Homo sapiens) [Search protein sequence]
DHQHIRYNPLQDEWVLVSAHRTVPRHDPLNPLCPGAIRANGEVNPQYDST
FLFDNDFPALQPDAPSPGPSDHPLFQAKSARGVCKVMCFHPWSDVTLPLM
SVPEIRAVVDAWASVTEELGAQYPWVQIFENKGAMMGCSNPHPHCQVWAS
SFLPDIAQREERSQQAYKSQHGEPLLMEYSRQELLRKERLVLTSEHWLVL
VPFWATWPYQTLLLPRRHVRRLPELTPAERDDLASIMKKLLTKYDNLFET
SFPYSMGWHGAPTGSEAGANWNHWQLHAHYYPPLLRSATVRKFMVGYEML
AQAQRDLTPEQAAERLRALPEVHY
3D structure
PDB5in3 Molecular basis of classic galactosemia from the structure of human galactose 1-phosphate uridylyltransferase.
ChainA
Resolution1.73 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N72 C75 S135 N173 S181 H184 H186 Q188
Catalytic site (residue number reindexed from 1) N30 C33 S93 N131 S139 H142 H144 Q146
Enzyme Commision number 2.7.7.12: UDP-glucose--hexose-1-phosphate uridylyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 G1P A F171 N173 Q188 F129 N131 Q146
BS02 ZN A E202 H301 H319 H321 E160 H259 H277 H279
BS03 H2U A P73 A81 F95 N97 D98 V128 H186 Q188 P31 A39 F53 N55 D56 V86 H144 Q146
BS04 G1P A V337 G338 E340 V295 G296 E298
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008108 UDP-glucose:hexose-1-phosphate uridylyltransferase activity
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006011 UDP-glucose metabolic process
GO:0006012 galactose metabolic process
GO:0033499 galactose catabolic process via UDP-galactose
Cellular Component
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5in3, PDBe:5in3, PDBj:5in3
PDBsum5in3
PubMed27005423
UniProtP07902|GALT_HUMAN Galactose-1-phosphate uridylyltransferase (Gene Name=GALT)

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