Structure of PDB 5in2 Chain A

Receptor sequence
>5in2A (length=156) Species: 6282 (Onchocerca volvulus) [Search protein sequence]
ARRAVAVLRGDAGVSGIIYFQQGSGGSITTISGSVSGLTPGLHGFHVHQY
GDQTNGCTSAGDHYNPFGKTHGGPNDRIKHIGDLGNIVAGANGVAEVYIN
SYDIKLRGPLSVIGHSLVVHANTDDLGQGTGNMREESLKTGNAGSRLACG
VIGIAA
3D structure
PDB5in2 Crystal structure of extracellular Cu/Zn Superoxide Dismutase from Onchocerca volvulus at 1.5 Angstrom; Insight into novel binding site and new inhibitors
ChainA
Resolution1.55 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H46 H48 H63 H71 H80 D83 H120 R146
Catalytic site (residue number reindexed from 1) H46 H48 H63 H71 H80 D83 H120 R146
Enzyme Commision number 1.15.1.1: superoxide dismutase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H63 H71 H80 D83 H63 H71 H80 D83
BS02 CU A H46 H48 H120 H46 H48 H120
Gene Ontology
Molecular Function
GO:0004784 superoxide dismutase activity
GO:0005507 copper ion binding
GO:0016209 antioxidant activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0006801 superoxide metabolic process
GO:0019430 removal of superoxide radicals
GO:0098869 cellular oxidant detoxification
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5in2, PDBe:5in2, PDBj:5in2
PDBsum5in2
PubMed
UniProtQ07449|SODE_ONCVO Extracellular superoxide dismutase [Cu-Zn] (Gene Name=sod-4)

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