Structure of PDB 5ihh Chain A

Receptor sequence
>5ihhA (length=116) Species: 9606 (Homo sapiens) [Search protein sequence]
CPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLT
TEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAA
LLSPYSYSTTAVVTNP
3D structure
PDB5ihh Modifications of the 7-Hydroxyl Group of the Transthyretin Ligand Luteolin Provide Mechanistic Insights into Its Binding Properties and High Plasma Specificity.
ChainA
Resolution1.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6B5 A K15 L17 L110 S117 T119 K6 L8 L101 S108 T110 MOAD: Kd=390nM
PDBbind-CN: -logKd/Ki=6.41,Kd=390nM
Gene Ontology
Molecular Function
GO:0005179 hormone activity
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0070324 thyroid hormone binding
Biological Process
GO:0006144 purine nucleobase metabolic process
GO:0007165 signal transduction
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0035578 azurophil granule lumen
GO:0070062 extracellular exosome

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Cellular Component
External links
PDB RCSB:5ihh, PDBe:5ihh, PDBj:5ihh
PDBsum5ihh
PubMed27050398
UniProtP02766|TTHY_HUMAN Transthyretin (Gene Name=TTR)

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