Structure of PDB 5ih9 Chain A

Receptor sequence
>5ih9A (length=308) Species: 9606 (Homo sapiens) [Search protein sequence]
MDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLPRIK
TEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLS
EEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCA
KSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYK
KIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNY
PVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLL
LLAKKARG
3D structure
PDB5ih9 Toward the Validation of Maternal Embryonic Leucine Zipper Kinase: Discovery, Optimization of Highly Potent and Selective Inhibitors, and Preliminary Biology Insight.
ChainA
Resolution1.79 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D132 K134 E136 N137 D150 S171
Catalytic site (residue number reindexed from 1) D127 K129 E131 N132 D145 S152
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6BF A I17 L27 A38 Y88 C89 P90 E93 L139 I149 I16 L26 A37 Y83 C84 P85 E88 L134 I144 MOAD: Kd=0.002uM
PDBbind-CN: -logKd/Ki=8.70,Kd=0.002uM
BindingDB: IC50=2.0nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5ih9, PDBe:5ih9, PDBj:5ih9
PDBsum5ih9
PubMed27187609
UniProtQ14680|MELK_HUMAN Maternal embryonic leucine zipper kinase (Gene Name=MELK)

[Back to BioLiP]