Structure of PDB 5ih8 Chain A

Receptor sequence
>5ih8A (length=306) Species: 9606 (Homo sapiens) [Search protein sequence]
MDYDELLKYYELHETIGTAKVKLACHILTGEMVAIKIMDKNTDLPRIKTE
IEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEE
ETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKS
LAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKI
MRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPV
EWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLL
AKKARG
3D structure
PDB5ih8 Toward the Validation of Maternal Embryonic Leucine Zipper Kinase: Discovery, Optimization of Highly Potent and Selective Inhibitors, and Preliminary Biology Insight.
ChainA
Resolution1.85 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D132 K134 E136 N137 D150 S171
Catalytic site (residue number reindexed from 1) D125 K127 E129 N130 D143 S150
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6BJ A E15 I17 L27 A38 E87 Y88 C89 P90 L139 I149 E14 I16 L23 A34 E80 Y81 C82 P83 L132 I142 MOAD: ic50=0.18uM
PDBbind-CN: -logKd/Ki=6.74,IC50=0.18uM
BindingDB: IC50=180nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5ih8, PDBe:5ih8, PDBj:5ih8
PDBsum5ih8
PubMed27187609
UniProtQ14680|MELK_HUMAN Maternal embryonic leucine zipper kinase (Gene Name=MELK)

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