Structure of PDB 5igm Chain A

Receptor sequence
>5igmA (length=113) Species: 9606 (Homo sapiens) [Search protein sequence]
STPIQQLLEHFLRQLQRKDPHGFFAFPVTDAIAPGYSMIIKHPMDFGTMK
DKIVANEYKSVTEFKADFKLMCDNAMTYNRPDTVYYKLAKKILHAGFKMM
SKERLLALKRSMS
3D structure
PDB5igm Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia.
ChainA
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BMF A F160 F161 F163 V165 I169 N216 Y222 F23 F24 F26 V28 I32 N79 Y85 MOAD: Kd=41.7nM
PDBbind-CN: -logKd/Ki=7.38,Kd=41.7nM
BindingDB: IC50=47nM,Kd=114nM
External links
PDB RCSB:5igm, PDBe:5igm, PDBj:5igm
PDBsum5igm
PubMed27757418
UniProtQ9H8M2|BRD9_HUMAN Bromodomain-containing protein 9 (Gene Name=BRD9)

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