Structure of PDB 5igl Chain A

Receptor sequence
>5iglA (length=139) Species: 9606 (Homo sapiens) [Search protein sequence]
LGTENLYFQSMQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPDYYK
MIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKT
AQEIVNICYQTITEYDEHLTQLEKDICTAKEAALEEAEL
3D structure
PDB5igl Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BMF A F1547 V1551 N1552 V1556 Y1601 N1602 Y1608 F36 V40 N41 V45 Y90 N91 Y97 MOAD: Kd=42.7nM
PDBbind-CN: -logKd/Ki=7.37,Kd=42.7nM
BindingDB: Kd=25000nM
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
GO:0016251 RNA polymerase II general transcription initiation factor activity
GO:0017025 TBP-class protein binding
Biological Process
GO:0006366 transcription by RNA polymerase II
Cellular Component
GO:0005669 transcription factor TFIID complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5igl, PDBe:5igl, PDBj:5igl
PDBsum5igl
PubMed27757418
UniProtQ8IZX4|TAF1L_HUMAN Transcription initiation factor TFIID subunit 1-like (Gene Name=TAF1L)

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