Structure of PDB 5igk Chain A

Receptor sequence
>5igkA (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB5igk Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia.
ChainA
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BMF A W81 F83 Q85 V87 K91 L92 N140 I146 W40 F42 Q44 V46 K50 L51 N99 I105 MOAD: Kd=41.8nM
PDBbind-CN: -logKd/Ki=7.38,Kd=41.8nM
BindingDB: Kd=42nM,IC50=116nM
External links
PDB RCSB:5igk, PDBe:5igk, PDBj:5igk
PDBsum5igk
PubMed27757418
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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