Structure of PDB 5if4 Chain A

Receptor sequence
>5if4A (length=151) Species: 9606 (Homo sapiens) [Search protein sequence]
DELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQ
RNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFG
AFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV
E
3D structure
PDB5if4 Discovery and biological characterization of potent myeloid cell leukemia-1 inhibitors.
ChainA
Resolution2.392 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6AK A H224 A227 F228 M231 V249 M250 V253 F254 N260 R263 L267 F270 G271 I294 H53 A56 F57 M60 V78 M79 V82 F83 N89 R92 L96 F99 G100 I123 MOAD: Ki<1nM
PDBbind-CN: -logKd/Ki=9.00,Ki<1nM
BindingDB: Ki=<1.000000nM
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:5if4, PDBe:5if4, PDBj:5if4
PDBsum5if4
PubMed27878989
UniProtQ07820|MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 (Gene Name=MCL1)

[Back to BioLiP]