Structure of PDB 5iez Chain A

Receptor sequence
>5iezA (length=151) Species: 9606 (Homo sapiens) [Search protein sequence]
DDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGV
QRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISF
GAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFH
V
3D structure
PDB5iez Discovery and biological characterization of potent myeloid cell leukemia-1 inhibitors.
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6AL A A227 F228 M231 M250 F254 R263 T266 L267 F270 G271 A57 F58 M61 M80 F84 R93 T96 L97 F100 G101 PDBbind-CN: -logKd/Ki=7.64,Ki=23nM
BindingDB: Ki=23nM
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:5iez, PDBe:5iez, PDBj:5iez
PDBsum5iez
PubMed27878989
UniProtQ07820|MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 (Gene Name=MCL1)

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