Structure of PDB 5icv Chain A

Receptor sequence
>5icvA (length=180) Species: 9606 (Homo sapiens) [Search protein sequence]
VPSSALSEVSLRLLCHDDIDTVKHLCGDWFPIEYPDSWYRDITSNKKFFS
LAATYRGAIVGMIVAEIKNRTKIHKEDGDILASNFSVDTQVAYILSLGVV
KEFRKHGIGSLLLESLKDHISTTAQDHCKAIYLHVLTTNNTAINFYENRD
FKQHHYLPYYYSIRGVLKDGFTYVLYINGG
3D structure
PDB5icv Crystal Structure of the Golgi-Associated Human N alpha-Acetyltransferase 60 Reveals the Molecular Determinants for Substrate-Specific Acetylation.
ChainA
Resolution1.53 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.259: N-terminal methionine N(alpha)-acetyltransferase NatF.
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A F34 I36 Y38 Y97 L99 Y165 F30 I32 Y34 Y93 L95 Y161
BS02 1XE A S100 L101 G102 V103 R108 K109 G111 G113 S114 H138 V139 F149 Y150 N152 R153 S96 L97 G98 V99 R104 K105 G107 G109 S110 H134 V135 F145 Y146 N148 R149 PDBbind-CN: -logKd/Ki=5.62,IC50=2.4uM
Gene Ontology
Molecular Function
GO:0004596 peptide alpha-N-acetyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups

View graph for
Molecular Function
External links
PDB RCSB:5icv, PDBe:5icv, PDBj:5icv
PDBsum5icv
PubMed27320834
UniProtQ9H7X0|NAA60_HUMAN N-alpha-acetyltransferase 60 (Gene Name=NAA60)

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