Structure of PDB 5icp Chain A

Receptor sequence
>5icpA (length=343) Species: 9606 (Homo sapiens) [Search protein sequence]
MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYA
LKQIEGTGISMSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYA
EHDLWHIIKFHRASKLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANI
LVMGEGPERGRVKIADMGFARLFNSPLKVVTFWYRAPELLLGARHYTKAI
DIWAIGCIFAELLTSEPIFHCRQESNPYHHDQLDRIFNVMGFPADKDWED
IKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMD
PIKRITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLTEE
3D structure
PDB5icp Structure-Based Optimization of Potent, Selective, and Orally Bioavailable CDK8 Inhibitors Discovered by High-Throughput Screening.
ChainA
Resolution2.18 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D151 K153 N156 D173 N181 T196
Catalytic site (residue number reindexed from 1) D144 K146 N149 D166 N174 T181
Enzyme Commision number 2.7.11.22: cyclin-dependent kinase.
2.7.11.23: [RNA-polymerase]-subunit kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 69Z A V27 Y32 V35 A50 K52 F97 A100 L158 D173 R356 V27 Y32 V35 A50 K52 F97 A100 L151 D166 R337 PDBbind-CN: -logKd/Ki=8.42,IC50=3.8nM
BindingDB: IC50=70nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5icp, PDBe:5icp, PDBj:5icp
PDBsum5icp
PubMed27490956
UniProtP49336|CDK8_HUMAN Cyclin-dependent kinase 8 (Gene Name=CDK8)

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