Structure of PDB 5iaw Chain A

Receptor sequence
>5iawA (length=228) Species: 9606 (Homo sapiens) [Search protein sequence]
LTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLILTEMATNH
VQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPSGH
SDLLEERIRNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPD
RQYIKDREAVEKLQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTFN
HHHAEMLMSWRVNDHKFTPLLCEIWDVQ
3D structure
PDB5iaw A Novel Class of Natural FXR Modulators with a Unique Mode of Selective Co-regulator Assembly
ChainA
Resolution2.58 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V299 K303 H313 I317 E467 V55 K59 H69 I73 E223
BS02 T73 A F284 L287 T288 A291 H447 W454 F461 L465 F40 L43 T44 A47 H203 W210 F217 L221
BS03 T73 A M265 P266 T270 M290 H294 S332 I335 Y369 M21 P22 T26 M46 H50 S88 I91 Y125
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
GO:0032052 bile acid binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0038183 bile acid signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:5iaw, PDBe:5iaw, PDBj:5iaw
PDBsum5iaw
PubMed28186695
UniProtQ96RI1|NR1H4_HUMAN Bile acid receptor (Gene Name=NR1H4)

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