Structure of PDB 5ia5 Chain A

Receptor sequence
>5ia5A (length=273) Species: 9606 (Homo sapiens) [Search protein sequence]
TTEIHPSCVTRQKVIGAGEFGEVYKGMLKTSKEVPVAIKTLKAGYTEKQR
VDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREK
DGEFSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSD
FGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKFTSASDVWSFGIVM
WEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQE
RARRPKFADIVSILDKLIRAPDS
3D structure
PDB5ia5 Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.
ChainA
Resolution1.776 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D739 A741 R743 N744 D757 D766 P780
Catalytic site (residue number reindexed from 1) D132 A134 R136 N137 D150 D159 P173
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GV0 A A644 K646 M667 Y694 M695 E696 G698 E706 L730 S756 D757 A37 K39 M60 Y87 M88 E89 G91 E99 L123 S149 D150 MOAD: Kd=25nM
PDBbind-CN: -logKd/Ki=7.60,Kd=25nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5ia5, PDBe:5ia5, PDBj:5ia5
PDBsum5ia5
PubMed27768280
UniProtP29317|EPHA2_HUMAN Ephrin type-A receptor 2 (Gene Name=EPHA2)

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