Structure of PDB 5i9z Chain A

Receptor sequence
>5i9zA (length=273) Species: 9606 (Homo sapiens) [Search protein sequence]
FTTEIHPSCVTRQKVIGAGGEVYKGMLKTKEVPVAIKTLKAGYTEKQRVD
FLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDG
EFSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFG
LSRVLIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSN
HEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERARRPKFADIVSILDK
LIRAPDSLKTLADFDPRVSIRLP
3D structure
PDB5i9z Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.
ChainA
Resolution1.698 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D739 A741 R743 N744 D757 P780
Catalytic site (residue number reindexed from 1) D130 A132 R134 N135 D148 P157
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 627 A I619 A644 K646 E693 Y694 M695 G698 L746 S756 I16 A35 K37 E84 Y85 M86 G89 L137 S147 MOAD: Kd=9nM
PDBbind-CN: -logKd/Ki=8.05,Kd=9nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5i9z, PDBe:5i9z, PDBj:5i9z
PDBsum5i9z
PubMed27768280
UniProtP29317|EPHA2_HUMAN Ephrin type-A receptor 2 (Gene Name=EPHA2)

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