Structure of PDB 5i8s Chain A

Receptor sequence
>5i8sA (length=179) Species: 10090 (Mus musculus) [Search protein sequence]
MVQAWYMDESTADPRKPHRAQPDRPVSLEQLRTLGVLYWKLDADKYENDP
ELEKIRKMRNYSWMDIITICKDTLPNYEEKIKMFFEEHLHLDEEIRYILE
GSGYFDVRDKEDKWIRISMEKGDMITLPAGIYHRFTLDEKNYVKAMRLFV
GEPVWTPYNRPADHFDARVQYMSFLEGTA
3D structure
PDB5i8s Metal-Dependent Function of a Mammalian Acireductone Dioxygenase.
ChainA
Resolution1.89 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.13.11.53: acireductone dioxygenase (Ni(2+)-requiring).
1.13.11.54: acireductone dioxygenase (Fe(2+)-requiring).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NI A H88 H90 E94 H133 H88 H90 E94 H133
BS02 LEA A F84 R96 F135 F84 R96 F135
Gene Ontology
Molecular Function
GO:0005506 iron ion binding
GO:0010308 acireductone dioxygenase (Ni2+-requiring) activity
GO:0010309 acireductone dioxygenase [iron(II)-requiring] activity
GO:0016151 nickel cation binding
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
GO:0051213 dioxygenase activity
Biological Process
GO:0009086 methionine biosynthetic process
GO:0019509 L-methionine salvage from methylthioadenosine
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5i8s, PDBe:5i8s, PDBj:5i8s
PDBsum5i8s
PubMed26858196
UniProtQ99JT9|MTND_MOUSE Acireductone dioxygenase (Gene Name=Adi1)

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