Structure of PDB 5i80 Chain A

Receptor sequence
>5i80A (length=126) Species: 9606 (Homo sapiens) [Search protein sequence]
STNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTE
3D structure
PDB5i80 Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains.
ChainA
Resolution1.4501 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 67B A W81 P82 V87 L92 N140 I146 W40 P41 V46 L51 N99 I105 MOAD: Kd=62nM
PDBbind-CN: -logKd/Ki=7.21,Kd=62nM
BindingDB: IC50=92nM
External links
PDB RCSB:5i80, PDBe:5i80, PDBj:5i80
PDBsum5i80
PubMed27219867
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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