Structure of PDB 5i75 Chain A

Receptor sequence
>5i75A (length=540) Species: 9606 (Homo sapiens) [Search protein sequence]
GERETWGKKVDFLLSVIGYAVDLGNVWRFPYICAQNGGGAFLLPYTIMAI
FGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYY
NTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTS
PAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKT
SGKVVWVTATFPYIALSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVW
IDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSG
FVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAII
FFLMLITLGLDSSFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFG
SLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVK
EMLGFSPGWFWRICWVAISPLFLLFIIASFLMSPPQLRLFQYNYPYWSII
LGYAIGTSSFICIPTYIAYRLIITPGTFKERIIKSITPET
3D structure
PDB5i75 X-ray structures and mechanism of the human serotonin transporter.
ChainA
Resolution3.49 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 68P A Y95 I172 F335 F341 G442 T497 G498 V501 Y19 I96 F259 F265 G366 T421 G422 V425 BindingDB: Ki=1nM,IC50=10.0nM,EC50=5100nM,Kd=2.6nM
BS02 CLR A W573 L577 W497 L501
BS03 69D A Q332 F335 E494 G498 P499 L502 F556 Q256 F259 E418 G422 P423 L426 F480 BindingDB: IC50=4700nM
BS04 NA A G94 Y95 V97 D98 L434 D437 S438 G18 Y19 V21 D22 L358 D361 S362
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:5i75, PDBe:5i75, PDBj:5i75
PDBsum5i75
PubMed27049939
UniProtP31645|SC6A4_HUMAN Sodium-dependent serotonin transporter (Gene Name=SLC6A4)

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