Structure of PDB 5i73 Chain A

Receptor sequence
>5i73A (length=540) Species: 9606 (Homo sapiens) [Search protein sequence]
GERETWGKKVDFLLSVIGYAVDLGNVWRFPYICAQNGGGAFLLPYTIMAI
FGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYY
NTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTS
PAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKT
SGKVVWVTATFPYIALSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVW
IDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSG
FVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAII
FFLMLITLGLDSSFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFG
SLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVK
EMLGFSPGWFWRICWVAISPLFLLFIIASFLMSPPQLRLFQYNYPYWSII
LGYAIGTSSFICIPTYIAYRLIITPGTFKERIIKSITPET
3D structure
PDB5i73 X-ray structures and mechanism of the human serotonin transporter.
ChainA
Resolution3.24 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 68P A Y95 D98 I172 F335 F341 T497 G498 V501 Y19 D22 I96 F259 F265 T421 G422 V425 BindingDB: Ki=1nM,IC50=10.0nM,EC50=5100nM,Kd=2.6nM
BS02 CLR A W573 L577 W497 L501
BS03 68P A R104 Q332 F335 E494 L502 F556 R28 Q256 F259 E418 L426 F480 BindingDB: Ki=1nM,IC50=10.0nM,EC50=5100nM,Kd=2.6nM
BS04 NA A A96 D98 N101 S336 N368 A20 D22 N25 S260 N292
BS05 NA A G94 V97 L434 G435 D437 S438 G18 V21 L358 G359 D361 S362
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:5i73, PDBe:5i73, PDBj:5i73
PDBsum5i73
PubMed27049939
UniProtP31645|SC6A4_HUMAN Sodium-dependent serotonin transporter (Gene Name=SLC6A4)

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