Structure of PDB 5i6d Chain A

Receptor sequence
>5i6dA (length=285) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
RYDSLLQALGNTPLVGLQRLSPRWDDGRDGPHVRLWAKLEDRNPTGSIKD
RPAVRMIEQAEADGLLRPGATILEPTSGNTGISLAMAARLKGYRLICVMP
ENTSVERRQLLELYGAQIIFSTAVATAKELAATNPSWVMLYQYGNPANTD
SHYCGTGPELLADLPEITHFVAGLGTTGTLMGTGRFLREHVANVKIVAAE
PRFVPELYDPEILTARYSVGAVDAVRRTRELVHTEGIFAGISTGAVLHAA
LGVGAGALAAGERADIALVVADAGWKYLSTGAYAG
3D structure
PDB5i6d Inhibitors of the Cysteine Synthase CysM with Antibacterial Potency against Dormant Mycobacterium tuberculosis.
ChainA
Resolution1.64 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K51 S265
Catalytic site (residue number reindexed from 1) K49 S242
Enzyme Commision number 2.5.1.113: [CysO sulfur-carrier protein]-thiocarboxylate-dependent cysteine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP A K51 N81 G184 T185 T186 T188 S265 A294 D295 K49 N79 G175 T176 T177 T179 S242 A271 D272
BS02 AU6 A K51 T78 S79 N81 T82 Q151 Y152 G184 A208 E209 P210 S265 K49 T76 S77 N79 T80 Q142 Y143 G175 A199 E200 P201 S242 MOAD: Kd=8uM
Gene Ontology
Molecular Function
GO:0004124 cysteine synthase activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0030170 pyridoxal phosphate binding
GO:0033847 O-phosphoserine sulfhydrylase activity
Biological Process
GO:0006535 cysteine biosynthetic process from serine
GO:0019344 cysteine biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5i6d, PDBe:5i6d, PDBj:5i6d
PDBsum5i6d
PubMed27379713
UniProtP9WP53|CYSM_MYCTU O-phosphoserine sulfhydrylase (Gene Name=cysM)

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