Structure of PDB 5i5z Chain A

Receptor sequence
>5i5zA (length=345) Species: 9606 (Homo sapiens) [Search protein sequence]
DDKMDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDK
DYALKQIEGTGISMSACREIALLRELKHPNVISLQKVFLSHADRKVWLLF
DYAEHDLWHIIKFHRASKANLPRGMVKSLLYQILDGIHYLHANWVLHRDL
KPANILVMGEGPERGRVKIADMGFARLFNSPLKTFWYRAPELLLGARHYT
KAIDIWAIGCIFAELLTSEPIFHCRQSNPYHHDQLDRIFNVMGFPADKDW
EDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLT
MDPIKRITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLTEE
3D structure
PDB5i5z 2,8-Disubstituted-1,6-Naphthyridines and 4,6-Disubstituted-Isoquinolines with Potent, Selective Affinity for CDK8/19.
ChainA
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D151 K153 N156 D173 N181 T196
Catalytic site (residue number reindexed from 1) D149 K151 N154 D171 N179 T184
Enzyme Commision number 2.7.11.22: cyclin-dependent kinase.
2.7.11.23: [RNA-polymerase]-subunit kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 68U A V27 Y32 A50 K52 F97 A100 H106 L158 R356 V30 Y35 A53 K55 F100 A103 H109 L156 R339 PDBbind-CN: -logKd/Ki=9.05,IC50=0.9nM
BindingDB: IC50=0.900000nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5i5z, PDBe:5i5z, PDBj:5i5z
PDBsum5i5z
PubMed27326329
UniProtP49336|CDK8_HUMAN Cyclin-dependent kinase 8 (Gene Name=CDK8)

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