Structure of PDB 5i59 Chain A

Receptor sequence
>5i59A (length=262) Species: 10116 (Rattus norvegicus) [Search protein sequence]
TRLKIVTIHQEPFVYVKPTMSDGTCVKKVICTGPHTVPQCCYGFCIDLLI
KLARTMNFTYEVHLVADGKFGTQERVNSNKKEWNGMMGELLSGQADMIVA
PLTINNERAQYIEFSKPFKYQGLTILVKKGTRITGINDPRLRNPSDKFIY
ATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAFIW
DSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHE
NGFMEDLDKTWV
3D structure
PDB5i59 Structural Basis for Negative Allosteric Modulation of GluN2A-Containing NMDA Receptors.
ChainA
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLY A F92 T126 R131 S179 S180 D224 F70 T103 R108 S156 S157 D201
BS02 67Q A P140 R247 S248 G249 P117 R224 S225 G226 PDBbind-CN: -logKd/Ki=6.95,IC50=112nM
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:5i59, PDBe:5i59, PDBj:5i59
PDBsum5i59
PubMed27618671
UniProtP35439|NMDZ1_RAT Glutamate receptor ionotropic, NMDA 1 (Gene Name=Grin1)

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