Structure of PDB 5i58 Chain A

Receptor sequence
>5i58A (length=257) Species: 10116 (Rattus norvegicus) [Search protein sequence]
STRLKIVTIHQEPFVYVKPTMSDGTCVKKVICTGPVPQCCYGFCIDLLIK
LARTMNFTYEVHLVADGKFGTQERVKEWNGMMGELLSGQADMIVAPLTIN
NERAQYIEFSKPFKYQGLTILVKKGTRITGINDPRLRNPSDKFIYATVKQ
SSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVL
EFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFME
DLDKTWV
3D structure
PDB5i58 Structural Basis for Negative Allosteric Modulation of GluN2A-Containing NMDA Receptors.
ChainA
Resolution2.52 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLY A F92 P124 L125 T126 R131 S179 S180 W223 D224 F69 P96 L97 T98 R103 S151 S152 W195 D196
BS02 67R A P140 Y143 R247 G249 P112 Y115 R219 G221 PDBbind-CN: -logKd/Ki=6.92,IC50=119nM
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:5i58, PDBe:5i58, PDBj:5i58
PDBsum5i58
PubMed27618671
UniProtP35439|NMDZ1_RAT Glutamate receptor ionotropic, NMDA 1 (Gene Name=Grin1)

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