Structure of PDB 5i4v Chain A

Receptor sequence
>5i4vA (length=260) Species: 9606 (Homo sapiens) [Search protein sequence]
VQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPASGSASQQR
FAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETA
RRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDD
AEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLR
FPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHEGSGSGS
HKILHRLLQD
3D structure
PDB5i4v Discovery of a Novel, Orally Efficacious Liver X Receptor (LXR) beta Agonist.
ChainA
Resolution2.61 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 67S A F271 T272 L274 E281 M312 F329 L330 H435 F54 T55 L57 E64 M95 F112 L113 H218 PDBbind-CN: -logKd/Ki=8.52,Ki=3nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006629 lipid metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:5i4v, PDBe:5i4v, PDBj:5i4v
PDBsum5i4v
PubMed26990539
UniProtP55055|NR1H2_HUMAN Oxysterols receptor LXR-beta (Gene Name=NR1H2);
Q15596

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