Structure of PDB 5i4n Chain A

Receptor sequence
>5i4nA (length=275) Species: 9606 (Homo sapiens) [Search protein sequence]
FHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKA
HRNYSESFFAAASMMSKLSHKHLVLNYGVCFCGDENILVQEFVKFGSLDT
YLKKNKNCINILWKLEVAKQLAAAMHFLEENTLIHGNVCAKNILLIREED
RKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDK
WSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKAAELANLINN
CMDYEPDHRPSFRAIIRDLNSLFHH
3D structure
PDB5i4n Uncoupling JAK2 V617F activation from cytokine-induced signalling by modulation of JH2 alpha C helix.
ChainA
Resolution1.54 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N673 K677 N678 D699
Catalytic site (residue number reindexed from 1) N137 K141 N142 D163
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A G554 T555 T557 I559 L579 K581 F628 V629 S633 N673 K677 N678 L680 G18 T19 T21 I23 L43 K45 F92 V93 S97 N137 K141 N142 L144 BindingDB: Kd=1300nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5i4n, PDBe:5i4n, PDBj:5i4n
PDBsum5i4n
PubMed27029346
UniProtO60674|JAK2_HUMAN Tyrosine-protein kinase JAK2 (Gene Name=JAK2)

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