Structure of PDB 5i4e Chain A

Receptor sequence
>5i4eA (length=959) Species: 9606,44689 [Search protein sequence]
EWTARRLVWVPSELHGFEAAALRDEGEEEAEVELAESGRRLRLPRDQIQR
MNPPKFSKAEDMAELTCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPY
KQLPIYTEAIVEMYRGKKRHEVPPHVYAVTEGAYRSMLQDREDQSILCTG
ESGAGKTENTKKVIQYLAHVASSPKGRKEPGVPGELERQLLQANPILEAF
GNAKTVKNDNSSRFGKFIRINFDVAGYIVGANIETYLLEKSRAIRQAKDE
CSFHIFYQLLGGAGEQLKADLLLEPCSHYRFLTNGPSSSPGQERELFQET
LESLRVLGFSHEEIISMLRMVSAVLQFGNIALKRERNTDQATMPDNTAAQ
KLCRLLGLGVTDFSRALLTPRIKVGRDYVQKAQTKEQADFALEALAKATY
ERLFRWLVLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINYT
NEKLQQLFNHTMFVLEQEEYQREGIPWTFLDFGLDLQPCIDLIERPANPP
GLLALLDEECWFPKATDKSFVEKVAQEQGGHPKFQRPRHLRDQADFSVLH
YAGKVDYKANEWLMKNMDPLNDNVAALLHQSTDRLTAEIWKDVEGIVGLR
RGMFRTVGQLYKESLSRLMATLSNTNPSFVRCIVPNHEKRAGKLEPRLVL
DQLRCNGVLEGIRICRQGFPNRILFQEFRQRYEILTPNAIPKGFMDGKQA
CEKMIQALELDPNLYRVGQSKIFFRAGVLAQLEEERASEQTKSDYLKRAN
ELVQWINDKQASLESRDFGDSIESVQSFMNAHKEYKKTEKPPKGQEVSEL
EAIYNSLQTKLREPFVAPAGLTPNEIDSTWSALEKAEQEHAEALRIELKR
QKKIAVLLQKYNRILKKLENWATTKSVYLGSNETGDSITAVQAKLKNLEA
FDGECQSLEGQSNSDLLSILAQLTELNYNGVPELTERKDTFFAQQWTGVK
SSAETYKNT
3D structure
PDB5i4e Mechanistic insights into the active site and allosteric communication pathways in human nonmuscle myosin-2C.
ChainA
Resolution2.25 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S200 G201 T205 N256 S259 S260 G481 E483
Catalytic site (residue number reindexed from 1) S152 G153 T157 N208 S211 S212 G433 E435
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AOV A N146 P147 S200 G201 G203 K204 T205 E206 N256 S259 S260 G481 N98 P99 S152 G153 G155 K156 T157 E158 N208 S211 S212 G433
BS02 MG A T205 S260 T157 S212
Gene Ontology
Molecular Function
GO:0003774 cytoskeletal motor activity
GO:0005524 ATP binding
GO:0051015 actin filament binding
Cellular Component
GO:0016459 myosin complex

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Molecular Function
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Cellular Component
External links
PDB RCSB:5i4e, PDBe:5i4e, PDBj:5i4e
PDBsum5i4e
PubMed29256864
UniProtP05095;
Q7Z406

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