Structure of PDB 5i3r Chain A

Receptor sequence
>5i3rA (length=302) Species: 9606 (Homo sapiens) [Search protein sequence]
RVFAVGRHQVTLEESLAEGGFSTVFLVRTHGGIRCALKRMYVNNMPDLNV
CKREITIMKELSGHKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQ
MNKKLQTGFTEPEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDG
GNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEMINLYGGK
PITTKADIWALGCLLYKLCFFTLPFGESQVAICDGNFTIPDNSRYSRNIH
CLIRFMLEPDPEHRPDIFQVSYFAFKFAAADCPVSNINNSSIPSALPEPM
TA
3D structure
PDB5i3r Crystal Structure of BMP-2-inducible kinase in complex with an Indazole inhibitor
ChainA
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D180 K182 N185 D198 N208 T226
Catalytic site (residue number reindexed from 1) D139 K141 N144 D157 N167 T185
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IDK A L57 G60 S63 V65 A77 M130 Y132 C133 R134 G136 Q137 E184 N185 L187 C197 D198 L16 G19 S22 V24 A36 M89 Y91 C92 R93 G95 Q96 E143 N144 L146 C156 D157 BindingDB: Ki=17nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5i3r, PDBe:5i3r, PDBj:5i3r
PDBsum5i3r
PubMed
UniProtQ9NSY1|BMP2K_HUMAN BMP-2-inducible protein kinase (Gene Name=BMP2K)

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