Structure of PDB 5i2k Chain A

Receptor sequence
>5i2kA (length=276) Species: 9606 (Homo sapiens) [Search protein sequence]
NHLSIVTLEEAPFVIVEDIDPETCVRNTVPCRKFVKINNSTNEGMNVKKC
CKGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKVNNVWNGMIGEVVYQRA
VMAVGSLTINEERSEVVDFSVPFVETGISVMVSRGTQVTGLSDKKFQRPH
DYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKFNQKGVEDALVSLKTGK
LDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQ
IDLALLQFVGDGEMEELETLWLTGIC
3D structure
PDB5i2k Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design.
ChainA
Resolution2.86 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLU A H87 S113 T115 R120 G171 S172 T173 Y213 D214 H80 S106 T108 R113 G164 S165 T166 Y206 D207
BS02 67H A I116 P129 F130 V131 E132 T242 G243 I109 P122 F123 V124 E125 T235 G236 BindingDB: EC50=131nM
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:5i2k, PDBe:5i2k, PDBj:5i2k
PDBsum5i2k
PubMed26919761
UniProtQ12879|NMDE1_HUMAN Glutamate receptor ionotropic, NMDA 2A (Gene Name=GRIN2A)

[Back to BioLiP]