Structure of PDB 5i2c Chain A

Receptor sequence
>5i2cA (length=301) Species: 9606 (Homo sapiens) [Search protein sequence]
MELHILEHRVRVLSVARPGLWLYTHPLIKLLFLPRRSRCKFFSLTETPED
YTLMVDEEGFKELPPSEFLQVAEATWLVLNVSSHQAAGVTKIARSVIAPL
AEHHVSVLMLSTYQTDFILVREQDLSVVIHTLAQEFDIYREVGGEPVPVT
RHGPSPTVHPIQSPQNRFCVLTLDPETLPAIATTLIDVLFYSHSTPKEAA
SSSPEPSSITFFAFSLIEGYISIVMDAETQKKFPSDLLLTLWRMVRIGGQ
PLGFDECGIVAQIAGPLAAADISAYYISTFNFDHALVPEDGIGSVIEVLQ
R
3D structure
PDB5i2c Mechanism of arginine sensing by CASTOR1 upstream of mTORC1.
ChainA
Resolution1.801 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ARG A S111 V112 L113 L273 G274 E277 I280 V281 T300 F301 F303 D304 S106 V107 L108 L252 G253 E256 I259 V260 T279 F280 F282 D283
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0034618 arginine binding
GO:0042802 identical protein binding
GO:0140299 molecular sensor activity
GO:0140311 protein sequestering activity
Biological Process
GO:0034198 cellular response to amino acid starvation
GO:1903577 cellular response to L-arginine
GO:1904262 negative regulation of TORC1 signaling
GO:1904263 positive regulation of TORC1 signaling
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0061700 GATOR2 complex

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Cellular Component
External links
PDB RCSB:5i2c, PDBe:5i2c, PDBj:5i2c
PDBsum5i2c
PubMed27487210
UniProtQ8WTX7|CAST1_HUMAN Cytosolic arginine sensor for mTORC1 subunit 1 (Gene Name=CASTOR1)

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