Structure of PDB 5i29 Chain A

Receptor sequence
>5i29A (length=139) Species: 9606 (Homo sapiens) [Search protein sequence]
DDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPDYYKVIVNPMD
LETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNV
CYQTLTEYDEHLTQLEKDICTAKEAALEEAELESLDPMT
3D structure
PDB5i29 Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains.
ChainA
Resolution1.21 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.48: histone acetyltransferase.
2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 67B A W1526 P1527 V1532 N1533 F1536 V1537 Y1582 N1583 Y1589 W27 P28 V33 N34 F37 V38 Y83 N84 Y90 MOAD: Kd=15nM
PDBbind-CN: -logKd/Ki=7.82,Kd=15nM
BindingDB: IC50=3600nM
BS02 CA A E1632 D1635 M1637 E133 D136 M138
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
GO:0016251 RNA polymerase II general transcription initiation factor activity
GO:0017025 TBP-class protein binding
Biological Process
GO:0006366 transcription by RNA polymerase II
Cellular Component
GO:0005669 transcription factor TFIID complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5i29, PDBe:5i29, PDBj:5i29
PDBsum5i29
PubMed27219867
UniProtP21675|TAF1_HUMAN Transcription initiation factor TFIID subunit 1 (Gene Name=TAF1)

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