Structure of PDB 5i1q Chain A

Receptor sequence
>5i1qA (length=135) Species: 9606 (Homo sapiens) [Search protein sequence]
DDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPDYYKVIVNPMDL
ETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNVC
YQTLTEYDEHLTQLEKDICTAKEAALEEAELESLD
3D structure
PDB5i1q Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains.
ChainA
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.48: histone acetyltransferase.
2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 67C A W1526 P1527 F1528 V1532 F1536 V1537 Y1582 N1583 Y1589 W26 P27 F28 V32 F36 V37 Y82 N83 Y89 MOAD: Kd=12nM
PDBbind-CN: -logKd/Ki=7.92,Kd=12nM
BindingDB: IC50=9900nM
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
GO:0016251 RNA polymerase II general transcription initiation factor activity
GO:0017025 TBP-class protein binding
Biological Process
GO:0006366 transcription by RNA polymerase II
Cellular Component
GO:0005669 transcription factor TFIID complex

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Cellular Component
External links
PDB RCSB:5i1q, PDBe:5i1q, PDBj:5i1q
PDBsum5i1q
PubMed27219867
UniProtP21675|TAF1_HUMAN Transcription initiation factor TFIID subunit 1 (Gene Name=TAF1)

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