Structure of PDB 5i13 Chain A

Receptor sequence
>5i13A (length=181) Species: 211044 (Influenza A virus (A/Puerto Rico/8/1934(H1N1))) [Search protein sequence]
GPLGSMEDFVRQCFNPMIVELAEKTMKEYGEDLKIETNKFAAICTHLEVC
FMYSDASKHRFEIIEGRDRTMAWTVVNSICNTTGAEKPKFLPDLYDYKEN
RFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDE
ESRARIKTRLFTIRQEMASRGLWDSFRQSER
3D structure
PDB5i13 Two Distinctive Binding Modes of Endonuclease Inhibitors to the N-Terminal Region of Influenza Virus Polymerase Acidic Subunit
ChainA
Resolution2.151 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A H41 D108 E119 I120 H46 D93 E104 I105
BS02 MN A E80 D108 E65 D93
BS03 4P9 A K34 A37 W188 F191 S194 E195 K39 A42 W173 F176 S179 E180 PDBbind-CN: -logKd/Ki=5.08,IC50=8.26uM
BindingDB: IC50=8300nM
BS04 4P9 A H41 D108 E119 K134 H46 D93 E104 K119 PDBbind-CN: -logKd/Ki=5.08,IC50=8.26uM
BindingDB: IC50=8300nM
Gene Ontology
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:5i13, PDBe:5i13, PDBj:5i13
PDBsum5i13
PubMed27088785
UniProtP03433|PA_I34A1 Polymerase acidic protein (Gene Name=PA)

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