Structure of PDB 5i0n Chain A

Receptor sequence
>5i0nA (length=489) Species: 9606,10665 [Search protein sequence]
ERNEFPEDPEFEAVVRQAELAIERCIFPERIYQSGSYFVKDPQGRIIAVF
KPKNEEPYGHLNPKWTKWLQKGTGNIFEMLRIDEGLRLKIYKDTEGYYTI
GIGHLLTKSPSLNAAKSELDKAIGRNTNGVITKDEAEKLFNQDVDAAVRG
ILRNAKLKPVYDSLDAVRRAALINMVFQMGETGVAGFTNSLRMLQQKRWD
EAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNLGRDCLVLNQGYLS
EAGASLVDQKLELNIVPRTKVVYLASETFNYSAIDRVKSRGKRNRIGLPP
KVGSFQLFVEGYKDADYWLRRFEAEPLPENTNRQLLLQFERLVVLDYIIR
NTDRGNDNWLIKYDCDWVVVKEPVIKVAAIDNGLAFPLKHPDSWRAYPFY
WAWLPQAKVPFSQEIKDLILPKISDPNFVKDLEEDLYELFKKDPGFDRGQ
FHKQIAVMRGQILNLTQALKDNKSPLHLVQMPPVIVETA
3D structure
PDB5i0n PI4K IIalpha bound to calcium
ChainA
Resolution2.28 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E1013 D1022
Catalytic site (residue number reindexed from 1) E84 D93
Enzyme Commision number 2.7.1.67: 1-phosphatidylinositol 4-kinase.
3.2.1.17: lysozyme.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A S137 K152 F263 V264 I345 D346 S36 K51 F308 V309 I380 D381
BS02 ATP A W359 R360 P363 F364 Q445 W394 R395 P398 F399 Q480
BS03 CA A N313 D346 N358 D381
Gene Ontology
Molecular Function
GO:0003796 lysozyme activity
GO:0004430 1-phosphatidylinositol 4-kinase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0009253 peptidoglycan catabolic process
GO:0016998 cell wall macromolecule catabolic process
GO:0031640 killing of cells of another organism
GO:0042742 defense response to bacterium
GO:0044659 viral release from host cell by cytolysis
Cellular Component
GO:0030430 host cell cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5i0n, PDBe:5i0n, PDBj:5i0n
PDBsum5i0n
PubMed
UniProtD9IEF7;
Q9BTU6|P4K2A_HUMAN Phosphatidylinositol 4-kinase type 2-alpha (Gene Name=PI4K2A)

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